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The treatment-policy estimand is closer to intention-to-treat: it estimates the effect regardless of whether participants stayed on treatment or used rescue therapies

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These findings should be interpreted cautiously, as changes in liver enzyme levels do not necessarily reflect histological improvement

Immunohistochemical staining Immunohistochemical staining was carried out on representative formalin-fixed, paraffin-embedded tissues using the Bond Polymer Refine Detection system (Leica Biosystems Newcastle Ltd., Newcastle, UK) according to the manufacturer's instructions, with minor modifications