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It is thought that the granules exist in distinct pools within the -cell, in either a readily-releasable pool or a reserve pool (figure 4)

The mechanistic rationale underlying SSRI development stemmed from the serotonergic hypothesis, which posits that reduced serotonergic neurotransmission contributes to depressive symptoms

If resting heart rate rises substantially above baseline or exceeds 100 beats per minute at rest, further evaluation may be appropriate

However, accumulating evidence has identified additional GI complications, including cholelithiasis, cholecystitis, gastroparesis, and bowel obstruction, which may warrant caution in susceptible individuals