pancreatitis from glp-1 GLP-1–Based Therapies: The Dilemma of Uncertainty GLP-1 | Pancreapedia

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A new ligand against the GPCR GLP-1R acts as a positive allosteric modulator, binding both the receptor and the orthosteric ligand, accessing the peptide ligand within the interface between transmembrane domains 1 and 2 of the receptor.