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The 12 mg group achieved 23.7% average weight loss (27.2 kg or 60 pounds), while the 9 mg group lost 20.0%

Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]

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These physical and hormonal shifts can make pre-existing symptoms more noticeable for some people

Currently Available Treatment Tirzepatide Tirzepatide is FDA-approved and available as Mounjaro (T2D) and Zepbound (obesity)

Some of the most concerning reports include patients suffering from serious gastroparesis, ileus (intestinal blockage), and potential death