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Although all DPP4is share a common mechanism of action, their chemical structures (Figure 5) vary considerably, which can lead to differences in their properties [81]

Ala 18 The mutation of GIP His 18 to Ala reinforced its insulinotropic effect

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The association between GLP-1 receptor agonist and diabetic ketoacidosis in the FDA adverse event reporting system

doi: 10.1016/j.ophtha.2006.10.023 [DOI] [PubMed] [Google Scholar] 16.Xu J, Xu L, Wang YX, You QS, Jonas JB, Wei WB