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AMPK activation in the VMH decreases energy expenditure (105107) and AMPK inhibition increases energy expenditure ( Figure 1 )

Lancet 2008;372:12401250

Not all pharmacies maintain the same quality standards, and purity varies

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This redundancy can be seen in transgenic animals, whereby the genetic absence of a single chemosensor doesn't always result in a phenotype, probably due to metabolic compensation from similar and overlapping pathways