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After treatment initiation, minimum heart rate increased by ~1.1 bpm and nighttime HRV (RMSSD) dropped by ~1.8 ms signs of increased physiological load and reduced parasympathetic recovery during sleep

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In analysis of independent outcomes, individuals with a history of an outcome of interest prior to the drug initiation were excluded

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/ Guangzhou Innogen Pharmaceutical Group Co., Ltd., Novo Nordisk A/S, PegBio Co., Ltd., Pfizer Inc., QL Biopharmaceutical Co., Ltd., Roche Holding AG, Sanofi S.A., Sciwind Biosciences Co., Ltd., Tonghua Dongbao Pharmaceutical Co., Ltd., Viking Therapeutics, Inc., Amgen Inc., BioLingus GmbH, D&D Pharmatech Inc., Gmax Biopharm LLC, Hanmi Pharmaceutical Co., Ltd., Vivani Medical, Inc., vTv Therapeutics Inc., Zealand Pharma A/S, Altimmune, Inc., Structure Therapeutics Inc