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Objectives: This review aims to evaluate the current evidence on GLP-1RAs in PsO and PsA, examine the underlying pathophysiological mechanisms, and highlight key areas for future research, with a particular emphasis on early PsA as a critical window for intervention

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Moreover, glucose neurotoxicity and accumulation of advanced glycation end products in the brain is observed

doi: 10.1056/NEJMoa0802987