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Preliminary analysis detected no difference in beta diversity between baseline versus post-treatment ( Supplementary Figure 4 ) and distinct microbial features between two drug users ( Supplementary Figure 5 ), but more data are needed for further interpretation

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This study was an observational cohort investigation using electronic health record data from the United States Department of Veterans Affairs and included 606,434 patients with type 2 diabetes who newly started either a GLP-1 medication or, as a comparator, a sodium-glucose cotransporter-2 inhibitor (a type 2 diabetes medication that doesnt affect appetite and reward pathways) based on filled outpatient pharmacy records