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Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

But the three popular ones: now Ozempic, Mounjaro, and Trulicity drove 70% of sales in 2023

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Usually mild, and manageable with a slow start Nausea Bloating Low energy in the first week Occasional constipation Most of this fades with time especially if you start low, go slow, and keep your meals simple and balanced