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GLP-1 (Glucagon-like peptide-1) is an incretin secreted from intestinal L cells

Psychological support should continue alongside any pharmacological treatment, as medications alone do not address the underlying psychological, emotional, and behavioural factors that contribute to binge eating disorder

While large-scale randomized controlled trials (RCTs) have focused on higher-dose protocols for regulatory approval, a growing number of physicians are reporting excellent results at significantly lower doses , especially in individuals who are metabolically healthy or seeking lifestyle optimization rather than aggressive weight loss

Tirzepatide exhibits a prolonged circulating half-life of approximately 120150 hours, enabling sustained receptor engagement [3]

During analysis it was observed that treatment with SAR425899 significantly decreased liver volume as well as the plasma glucagon levels

doi: 10.1056/NEJMsa1909301, PMID: [DOI] [PubMed] [Google Scholar] 4