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Discover the effects of metformin on incretin signaling in MIN6 -cells

In this paper, the authors describe the energy state-dependent regulation of the PVNGLP-1R to DVC circuit, resulting in altered food intake and metabolic health, mediated by GLP-1 receptor signalling.

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Objective This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework

PlexusDx explains the physiological reasons behind this discomfort and shares evidence-based strategies to minimize pain during your weekly doses

New research presented at the Endocrine Society's ENDO 2026 meeting is generating interest among clinicians who manage obesity, testosterone deficiency, and male reproductive health