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Studied in the context of: Promoting significant weight loss (clinical trials showed over 20% body weight reduction in some patients) Dramatically improving insulin sensitivity and blood sugar control Increasing energy expenditure by enhancing lipolysis (fat breakdown) and fat oxidation Suppressing appetite and cravings, leading to reduced caloric intake Slowing gastric emptying, which prolongs fullness and further curbs appetite Enhancing glucose-dependent insulin secretion (more insulin release when blood sugar is high) Reducing glucagon levels and hepatic glucose output, helping to lower fasting blood glucose Improving cardiometabolic health markers (like lowering liver fat and possibly improving cholesterol profiles)

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While payers assess value through clinical and economic frameworks, patient preferences are driven by simple, tangible attributes: how much weight will they lose, how quickly, how tolerable is the experience and how much will it cost them (Figure 2)