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10.1016/j.euroneuro.2014.06.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Dissanayaka D

Paediatr Drugs

NHS weight management pathways follow NICE guidance, which recommends licensed treatments such as orlistat, semaglutide (Wegovy), or tirzepatide (Mounjaro) alongside lifestyle interventions

The STEP program (Semaglutide Treatment Effect in People with obesity) followed participants for up to 68 weeks, with those staying on medication maintaining 80% of their weight loss, while those who stopped regained nearly two-thirds of the weight within one year

Benefits: Direct anabolic effect on muscle

Oral agents and future generics may also be helpful