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Kevin, an additional concern with GLP-1 drugs, and rapid weight loss in general, is muscle wasting , especially in people over 40

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Future research will help us better understand whether the additional weight loss seen with tirzepatide translates into superior long-term health benefits compared with other GLP-1 therapies. While tirzepatide may lead to greater weight loss, a semaglutide medication may be more suitable for some people
J Clin Invest 133(3):e167952 Kusminski CM, Perez-Tilve D, Mller TD, DiMarchi RD, Tschp MH, Scherer PE (2024) Transforming obesity: The advancement of multi-receptor drugs
