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That includes the anti-inflammatory effect, the ability to reduce cell death and promote autophagy, and also its indirect effects through blood pressure, obesity, and glucose/lipid metabolism

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Synthetic human GLP-1 administered into the jugular vein of male rats acutely increased systolic and diastolic BP, as well as HR, which returned to basal levels 25 min after GLP-1 administration

In fact, the concomitant action on three key metabolic pathways could be more effective in reducing body weight and in the treatment of obesity, promoting the reduction in food intake (GLP-1, glucagon), the increase in energy expenditure (glucagon) and in peripheral glucose uptake with potentiation of GLP-1-induced weight loss (GIP), mitigating the hyperglycemic effect of glucagon

2019;50:212-224.e4

References Sharon, G