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Description

Excretion: The major route of sitagliptin elimination is renal, with 79% of the administered dose excreted unchanged in the urine

Abbreviations DPP-4: Dipeptidyl-peptidase 4 EXAMINE: Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care GLP-1: Glucagon-like peptide 1 PYO: Patient-year of exposure SAVOR-TIMI 53: The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)Thrombolysis in Myocardial Infarction (TIMI) 53 trial References Butler PC, Elashoff M, Elashoff R, Gale EA (2013) A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe

Side Effects The most common side effects of GLP-1 receptor agonists include nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during the initial dose escalation

Am J Respir Crit Care Med

Amino Acid Coupling: Each amino acid is coupled to the growing peptide chain via a condensation reaction, typically using carbodiimide or other coupling reagents