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This study demonstrates how database studies rooted in benchmarks against previously conducted randomized trials for the drugs of interest can produce complementary evidence to support expanded cardiovascular indications

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The decision to add B12 is made by individual prescribers working with compounding pharmacies, which is why B12 only appears in compounded formulations

Individuals with underlying kidney disease or diabetes requiring close glucose monitoring during illness should also seek provider guidance, as acute infection can alter insulin needs and medication tolerance

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