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Compounds 47 and 48 (Figure 6), with IC 50 values of 0.83 and 0.43 M, respectively, which possess aryl-substituted piperazines with acetamide linkers, showed the best activity as DPP-4 inhibitors

McPheeters M, OConnor EA, Riley S, Kennedy SM, Voisin C, Kuznacic K, et al

Dankner, R

[13] The FDA also considered data from one separate trial (NCT01720446 [74] ), which was sponsored by Novo Nordisk, of 3297 participants with type 2 diabetes who were at high risk for cardiovascular events

This change may reduce infrastructure complexity and associated costs for manufacturers whose internal capabilities include fill-finish operations

The semaglutide group showed a significantly improved Kansas City Cardiomyopathy Questionnaire clinical summary score and a longer 6-min walking distance from baseline (21.5 m and 1.2 m in the semaglutide and placebo groups, respectively, intergroup difference 20.3 m, 95% CI 8.632.1 m), compared with that in the placebo group despite the relatively short observation period of 52 weeks