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The starting dose was 0.6 mg/day with weekly increments of 0.6 mg until reaching a dose of 3.0 mg/day

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Our findings reveal that tirzepatide attenuates alcohol-induced dopamine signalling, reduces alcohol consumption, and suppresses relapse-like behaviours. Because alcohol, nicotine, and many drugs of abuse hijack the brains reward circuitry, dampening dopamine spikes could help explain why alcohol seemed less compelling to the animals

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eGFR slopes (once measured at -5 to -10 ml/min/1.73m2 per year) now approach what many consider in line with physiological aging eGFR decline

Hepatology 68 , 15741588 (2018)