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p = 0.48)

Too high a dose may suppress appetite to the point where eating enough to support muscle growth becomes difficult

Holst and coworkers in Copenhagen generated antibodies against peptides synthesized according to the deduced sequences, and used radioimmunoassays to analyse the occurrence, processing pattern, and secretion of immunoreactive glucagon-like peptides (GLPs) from the pancreas and the gut and found, in analogy with the differential processing of the N-terminal part of proglucagon (= glicentin), a similar differential processing also of the remaining part of proglucagon (50): in the pancreas, this resulted in formation and secretion of MPGF (45) (major proglucagon fragment), whereas in the gut there was both formation of and separate release of immunoreactive GLP-1 and GLP-2

But its important to see GLP-1s as a springboard, not a destination

Most patients regain weight after stopping GLP-1 medications, with clinical trials showing approximately two-thirds of lost weight returns within one year
