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Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal

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The glucose-lowering efficacy measured by the decrease in HbA1c was dose-dependent in the tirzepatide group and did not plateau [52]

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Clinical studies have indicated a notable increase in circulating total IGF-1 levels in early-stage late-onset AD patients compared to controls [126]

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