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GLP-1 receptor agonists downregulate aberrant GnT-III expression in alzheimers disease models through the Akt/GSK-3beta/beta-catenin signaling

GLP-1R is expressed in multiple cardiovascular cell types such as monocyte/macrophages, smooth muscle cells, endothelial cells, and cardiomyocytes

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One study found a mean weight loss of 5.2 kg at six months with improved reproductive outcomes

I provide details regarding the development of GLP-1 receptor agonists for anti-obesity therapy and discuss the possible mechanism behind their beneficial effects on adverse cardiovascular events

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