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NAION (non-arteritic anterior ischemic optic neuropathy) is a type of painless eye stroke that can cause sudden, irreversible vision loss

J Surg Res 143(1):99108 Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R (2008) Insights into the regulation of TNF- production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition

The FDA removed tirzepatide from the drug shortage list in December 2024 and semaglutide in February 2025, eliminating the primary legal basis for "essentially a copy" compounding of these substances

Compounded drugs can be important for overcoming shortages or meeting unique patient needs but compounders should not try to compound drugs in a way that circumvents FDAs approval process. Non-FDA-Approved GLP-1 Drugs This follows last months announcement that the FDA plans to take decisive steps in restricting non-FDA-approved GLP-1 receptor agonists

They are particularly valuable for patients with established cardiovascular disease, heart failure, or chronic kidney disease
