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For example: A meta-analysis of 76 randomized trials found that use of GLP-1 receptor agonists (the drug class Ozempic belongs to) raises the risk of gallbladder and biliary diseasesespecially at higher doses or over longer durationswith relative risks ranging from 1.27 to 1.55 depending on the condition

Long-term real-world data from clinical practices has not revealed organ damage or accumulating toxicity with multi-year use

Individual research outcomes vary with dose and duration

Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, et al