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While the fundamentals are likely to remain the same (all GLP-1 drugs, for example, work by suppressing appetite, meaning smaller portions are essential), how people react to newer drugs could throw up plenty of surprises

doi: 10.1038/s41569-023-00849-3 9 BaggioLLDruckerDJ

Jama , 321 (15), 1457-1458.

This effect appears to explain the carbohydrate stimulated ileal brake where plasma GLP-1 increases without a change in PYY (64)

Some patients report slightly less nausea with oral semaglutide, though both forms achieve the same therapeutic effect

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