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Description
It is not appropriate during pregnancy and must be used with caution alongside certain other medications

Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes (SURPASS-2)
There is no known pharmacological interaction from same-day administration
These are the trials the FDA will scrutinize most closely

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In large clinical trials, some people lost around 20 percent of their starting weight with tirzepatide