is retatrutide more effective than tirzepatide vs — What to Know Before You Decide Semaglutide vs Tirzepatide vs Retatrutide:

Vomiting, diarrhea, and constipation also occur

Supplement considerations Multivitamin supplementation becomes important during rapid weight loss

Many patients find that week three or four becomes notably easier once their system adjusts to the medication's appetite-suppressing effects

But it can also create unexpected challenges

Phase 3: Optimization (weeks 13 and beyond) At maintenance dose with stabilized side effects, your injection day becomes primarily about consistency and lifestyle fit

Thankfully, most GLP-1 shortages have been resolved since early 2025, but a shortage can also drive people to switch from tirzepatide to semaglutide, or semaglutide to tirzepatide