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Pancreatitis and biliary disease have also been reported
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In comparative studies, complete suppression of -arrestin recruitment produced slower internalization, reduced downregulation, and longer-lasting cAMP signaling than semaglutide [52], indicating that semaglutide retains functionally meaningful arrestin engagement, even if not at the highest level among GLP-1R agonists

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J., et al., Comparative Effectiveness Review Methods: Clinical Heterogeneity (Agency for Healthcare Research and Quality (US), 2010) accessed October 22, 2025, [PubMed] [Google Scholar] 28
