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The present findings on GLP-1RA use in T2DM patients are concordant with results of prior meta-analyses from our group 13 and others (summarized in Supplemental Table S1), 14 20 as well as data from real-world observational and pharmacovigilance studies, 43,44 that have established the robust cardiovascular and cerebrovascular benefits from GLP-1RAs in T2DM and laid the ground for their broader incorporation in clinical practice guidelines

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Treatment with empagliflozin in patients with T2D improves cardiac efficiency and energy by increasing circulating ketone concentration, thus representing a sparing fuel for the heart [105,106,107]

GLP-1 (glucagonlike peptide1) and GIP (Gastric inhibitory polypeptide) are incretin hormones that play a crucial role in regulating glucose levels and promoting weight loss