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To evaluate the soundness of the results of main analyses, we conducted sensitivity analyses for the subpopulation without any diagnosis of other potential indications, including diabetic neuropathy, seizure, postherpetic neuralgia, neuropathic pain, or restless leg syndrome

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The increase in oestrogen levels is attributed to an increase in the activity of aromatase within adipose cells particularly those seen in the breast tissue [32, 76]

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