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Sci Transl Med 2023

The ability of AMG 133 to lower body weight and improve metabolic markers in male obese mice and cynomolgus monkeys is reported by researchers, who also confirm the GIP receptor antagonist and GLP- 1 receptor agonist activities in cell-based systems

Continuing on to discontinuation rates we see another very interesting nugget that I have bolded below: Discontinuation rates due to adverse events were 12.2% and 18.2% with retatrutide 9 mg and 12 mg, respectively, compared to 4.0% with placebo

But they represent a genuine shift toward understanding health as an ecosystem rather than a series of isolated biochemical targets

Goldman, MD, is a board-certified endocrinologist

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