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2021;22(5) doi: 10.3390/ijms22052350

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Omar-Hmeadi M, Lund PE, Gandasi NR, Tengholm A, and Barg S, Paracrine Control of -Cell Glucagon Exocytosis Is Compromised in Human Type-2 Diabetes, Nature Communications 11, no

Over a 48 week treatment period, these combined effects support steady, sustainable weight loss while improving overall metabolic health

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Metformin enhances insulin sensitivity through mitochondrial and AMPK-dependent mechanisms, while semaglutide enhances insulin secretion and reduces appetite through incretin signaling