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These findings offer a mechanistic foundation for exploring GLP-1RAs as novel anti-inflammatory therapies in IBD, bridging gut physiology with immune modulation

This combination has been investigated in Phase 3 clinical research for its proposed dual-pathway modulation involving amylin and incretin systems

Sin embargo, el hecho de que otros autores hayan demostrado que en el miocardio porcino el tratamiento con exenatida inhibe la apoptosis y el estrs oxidativo y activa quinasas de supervivencia tras un procedimiento de isquemia-reperfusin45, plantea la necesidad de disear nuevos estudios para clarificar el impacto beneficioso de las estrategias basadas en GLP-1 en este tipo de modelo experimental