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But Shin says whats really needed is information from randomized, double-blinded studies, in which participants are followed forward in time and given either a drug or a placebo

doi: 10.2337/diab.45.6.832 144 HunterKHlscherC

I've had it 'under control' for a few years now, but it's never completely gone away

doi: 10.1146/annurev-physiol-021113-170317

Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonist albiglutide (HARMONY 1 trial): 52-week primary endpoint results from a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes mellitus not controlled on pioglitazone, with or without metformin

This becomes particularly important since inflammation in people with obesity may reduce blood-brain barrier integrity 28