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Both approaches reduce overall food intake

Methotrexate + Trimethoprim Severe bone marrow suppression 9

Achieving a healthy weight with ketogenic therapy is not considered remission of obesity, because its assumed that either the ketogenic therapy will stop working or the patient (or physician) will not maintain the diet

Wei R, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Neeland I.J., Linge J., Birkenfeld A.L

(2023): The Half-Life Problem That Makes Retatrutide Dosing Non-Obvious Retatrutide has a mean elimination half-life of approximately 6 days (144165 hours) across therapeutic dose ranges, per Coskun et al
