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10.1056/NEJMoa1509225 [DOI] [PubMed] [Google Scholar] 11.Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, et al

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Accessed January 9, 2025.

By preserving beta-cell function through the incretin system and reducing insulin resistance through metformin, researchers are evaluating if this combination can delay the need for insulin therapy longer than other oral agents