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made the analysis plan, researched data, performed analyses, contributed to the discussion and wrote the first draft of the manuscript

In terms of reduction in BMI, 11 studies (with 349 and 310 subjects from the experimental and control groups, respectively) were included in the analysis

Importantly, these associations persist after accounting for improvements in glycemic control and body weight, suggesting that the observed neuroprotective signal may not be solely attributable to better metabolic management

Sachs S, Bastidas-Ponce A, Tritschler S, et al

Some patients also report headaches , gastrointestinal discomfort , anxiety , and sleep disturbances

Nausea or mild stomach discomfort often appears during early stages of treatment and usually improves as dosage adjustments stabilize hormone activity