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It makes sense from a clinical standpoint

GLP-1 medications are FDA-approved and clinically proven to help regulate appetite, support blood sugar balance, and promote sustainable weight loss when combined with healthy lifestyle changes

Semaglutide GLP-1 also helps patients burn more calories through increased metabolism and body temperature

Uncontrolled gastric emptying means that the valve at the bottom of your stomach, the pyloric valve, simply opens and dumps everything out, before your stomach has finished digesting

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Previously, the ACHIEVE-1 study evaluated orforglipron monotherapy in people with early type 2 diabetes uncontrolled with lifestyle intervention, and demonstrated a 12 mmol/mol (1.1%) greater HbA 1c reduction and a 5.9% greater body weight reduction than placebo (Rosenstock et al, 2025)