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Phase 2 clinical trial data for Retatrutide was published by Jastreboff et al

In people with CKD and T2D, first- and second-generation mineralocorticoid receptor antagonists (MRAs) have been used for resistant hypertension and heart failure with reduced ejection fraction

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ASA 81 mg is as effective as ASA 325 mg for reducing cardiovascular events ASA 325 mg does not cause more bleeding episodes than ASA 81 mg ASA dosing should be based on a clinician-patient risk discussion incorporating patients risk profile and their values and preferences Future trials should ensure adequate representation of women and race/ethnic minorities The results of the present trial suggest that either dose of ASA (81 mg or 325 mg) would be adequate to lower patients risk of death or atherosclerotic cardiovascular events with similar risk of bleeding
