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The good news is that for most people, these side effects peak early and then decline

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Who might not be suitable

doi: 10.1080/15563650.2022.2060116

GLP-1RAs with proven benefit are even recommended as a first-line therapy in people with T2D and atherosclerotic CVD or at high/very high CV risk without prescribing metformin (20), despite the fact that CVOTs testing GLP-1RAs have mainly been performed in metformin-treated patients

This desensitization is one reason some patients experience a plateau effect where appetite suppression weakens despite increasing doses
