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In both mice and rats, administration of ICV exendin-4(939) (Ex9), a potent GLP-1r antagonist, during oral glucose impairs glucose tolerance and reduces insulin levels (104, 209, 229)

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And it can cross the blood-rain barrier, reduce inflammation and oxidative stress, and protect synapses and neurons, showing neuroprotective effects in animal models of AD and PD (Hong et al., 2024)

4,24 In clinical trials thus far, GLP-1 agonists have shown their weight-loss effects only in conjunction with diet and exercise

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It also slows gastric emptying, so sulfur burps occur with tirzepatide as well