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Description
Estudios experimentales han determinado que estos frmacos disminuyen la expresin de la metaloproteinasas 2, que se encargan del remodelamiento de la matriz extracelular, reduce la infiltracin monocitaria en el endotelio vascular, la expresin de molculas de adhesin celular y promueve el cambio fenotpico de los macrfagos M1 (pro-inflamatorios) al M2 (anti-inflamatorios)

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This is the FDA-approved starting dose kept as a maintenance dose, an approach some patients and providers use for gastrointestinal tolerability, for keeping weight off after a loss, and for lower-dose support of metabolic biomarkers at a lower monthly cost

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Noyan-Ashraf MH, et al
