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Description
Formal analysis: Xilong Li
10.1038/npp.2015.362 55 SharmaA
Proglucagon is stored in intracellular granules where it undergoes post-translational processing and is cleaved by prohormone convertase 1/3 to produce peptides such as GLP-1 (Orskov et al., 1986)
These actions contribute to reduced systemic and local inflammation, improved endothelial function, and decreased oxidative stress [10]
Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes
[PubMed ID: 6074000]
