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The GLP-1 receptor agonist semaglutide reduces risks of kidney function loss, kidney failure, cardiovascular events, cardiovascular death and all-cause mortality in people with CKD and T2DM Ongoing clinical and mechanistic studies are expected to expand use of GLP-1 receptor agonists, GLP-1/GIP and other metabolic hormones for the treatment of CKD At the moment the most complete data is available for semaglutide from SUSTAIN-6 and FLOW trial which is the only trial with primary renal outcome in T2DM patients out of all GLP-1 RA Very good data for renal outcomes as secondary ones available for GLP-1 RAs dulaglutide and liraglutide and GLP-1/GIP RA tirzepatide, Very interesting and positive data from mechanistic REMODEL trial with semaglutide in T2DM patients presented but not yet published (reduced perirenal fat, rernal fibrosis and much more) Based on following excellent papers: #glp1 #gip #semaglutide #tirzepatide #liraglutide #dulaglutide #kidney #ckd #chronickidneydisease #cardiovascularcomplications Martin Haluzks Post -1 Incretins have an important role in glucose homeostasis, regulation of appetite, energy expenditure and immunity

A head-to-head comparison is going to be necessary to see the actual long-term comparison of weight loss, he says

Individualised cessation strategies and long-term support are essential to sustain treatment benefits and prevent the reversal of clinical progress

doi: 10.1111/jnc.13731 72 NassarNNAl-ShorbagyMYArabHHAbdallahDM

Semaglutide works in the following ways: Semaglutide improves insulin secretion from the beta cells in the pancreas

La dosificacin comienza en un nivel bajo y se aumenta gradualmente segn se tolere para maximizar los beneficios y minimizar los efectos secundarios