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In the U.S., tirzepatide is listed at $1,023 per month , compared to just $319 in Japan more than three times higher

Hypertension, dyslipidemia, prediabetes, obstructive sleep apnea, and osteoarthritis are all qualifying comorbidities and all of them improve meaningfully with 1015% weight reduction

Practical and economic considerations

Balancing the strong evidence for both benefit and harm is challenging

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Because these medications reduce appetite and slow stomach emptying, people may eat less and feel full longer, which can lead to lower fluid intake if hydration isnt intentional