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There is no current evidence that retatrutide reduces cardiovascular events

Even accounting for long-term health gains, the researchers found that GLP-1 drugs fall well short of standard benchmarks for cost-effectiveness

Locally increased GLP-1 levels might exert paracrine functions on IEL (50) and afferent neurons, impacting mucosal immune responses and feeding patterns, respectively

GLP-1s reduce appetite

Long-acting GLP-1 receptor agonists improve glycemic control in type 2 diabetes patients while posing a low risk of hypoglycaemia due to their glucose-dependent mode of action

[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Shahisavandi M., Wang K., Ghanbari M., Ahmadizar F