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Rational design of a combination medication for the treatment of obesity

Technology Transfer and Scale-Up Technology transfer moving a manufacturing process from R&D into commercial production or between sites is a critical enabler (and bottleneck) for GLP-1 manufacturing expansion

These data suggest a lower risk of serious CV events and improved health status among tirzepatide-treated patients with heart failure and obesity compared with placebo

Wolf, Kelly J

The trial also featured a "novel, patient-centric approach to clinical trial design." Placebo participants who regained 50% or more of their weight were eligible for rescue therapy with orforglipron

Amy also critiques microbiome-focused research, highlights the central role of metabolic health (insulin, triglycerides, weight), and offers practical perspective on using nutritional ketosis as a hopeful, science-based strategy for dementia prevention and treatment