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For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

GLP-1 receptor agonists are licensed for type 2 diabetes and weight management, not specifically for cholesterol reduction

Notwithstanding, we did find an association with other complications and with overall mortality

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fat mass, not just scale weight) Tracking body weight alone is insufficient it does not distinguish between fat loss and muscle loss, which is the key metric for outcome quality on GLP-1 therapy

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