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However, they have not been shown to reduce weight
C-reactive protein (CRP), an acute-phase protein, serves as a surrogate marker of systemic inflammation in humans

[DOI] [PubMed] [Google Scholar] 65.Scott RB, Kirk D, MacNaughton WK, Meddings JB

The MHRA and EMA include pancreatitis warnings in prescribing information, though current evidence suggests benefits generally outweigh risks in appropriately selected patients
And drugging this target has proven hard
